Interactive design and synthesis of a novel antibacterial agent
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چکیده
منابع مشابه
Design, Synthesis, Molecular Docking, and Antibacterial Evaluation of Some Novel Flouroquinolone Derivatives as Potent Antibacterial Agent
OBJECTIVE Quinolone moiety is an important class of nitrogen containing heterocycles widely used as key building blocks for medicinal agents. It exhibits a wide spectrum of pharmacophores and has bactericidal, antiviral, antimalarial, and anticancer activities. In view of the reported antimicrobial activity of various fluoroquinolones, the importance of the C-7 substituents is that they exhibit...
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15 صفحه اولDesign, Synthesis Potential Novel Antibacterial Agents
Substituted thiazolo ring-fused 2-pyridones, called pilicides, possess novel antibacterial properties and inhibit pilus assembly in Uropathogenic Escherichia coli. Recently, a small number of oxygen analogues of active pilicides have shown maintained ability to disrupt pilus assembly. Here an improved methodology for the synthesis of oxazolo ring-fused 2pyridones is presented, allowing dihydro ...
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A series of hydroxysemicarbazone derivatives of substituted diaryl ketones and acetophenones were synthesized and their structures were confirmed by analytical and spectroscopic methods including elemental analysis, infrared and nuclear magnetic resonance spectroscopy. The derivatives were prepared by a condensation reaction between N-hydroxysemicarbazide and substituted diaryl ketones or aceto...
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A series of hydroxysemicarbazone derivatives of substituted diaryl ketones and acetophenones were synthesized and their structures were confirmed by analytical and spectroscopic methods including elemental analysis, infrared and nuclear magnetic resonance spectroscopy. The derivatives were prepared by a condensation reaction between N-hydroxysemicarbazide and substituted diaryl ketones or aceto...
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ژورنال
عنوان ژورنال: Canadian Journal of Chemistry
سال: 1994
ISSN: 0008-4042,1480-3291
DOI: 10.1139/v94-133